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NEUROLOGY 2006;66:1108-1110
© 2006 American Academy of Neurology
Brief Communications

Opioidergic changes in the pineal gland and hypothalamus in cluster headache: A ligand PET study

T. Sprenger, MD, F. Willoch, PhD, M. Miederer, MD, F. Schindler, MD, M. Valet, MD, A. Berthele, MD, M. E. Spilker, PhD, S. Förderreuther, MD, A. Straube, MD, I. Stangier, MS, H. J. Wester, PhD and T. R. Tölle, MD, PhD

From the Departments of Neurology (T.S., M.M., F.S., M.V., A.B., T.R.T.) and Nuclear Medicine (MM., M.E.S., I.S., H.J.W.), Klinikum rechts der Isar, Technische Universität München, Germany; Department of Radiology (F.W.), Rikshospitalet Oslo, Norway; and Department of Neurology (S.F., A.S.), Klinikum Großhadern, Ludwig-Maximilians-Universität München, Germany.

Using PET with the opioidergic ligand [11C]diprenorphine, the authors demonstrate decreased tracer binding in the pineal gland of cluster headache patients vs healthy volunteers. Opioid receptor availability in the hypothalamus and cingulate cortex depended on the duration of the headache disorder. Therefore, the pathophysiology of cluster headache may relate to opioidergic dysfunction in circuitries generating the biologic clock.

Supported by the Irmgard und Gerhard Schulz Fond, the SFB 391 C9, and a grant from the Deutsche Migräne und Kopfschmerzgesellschaft (DMKG).

Disclosure: The authors report no conflicts of interest.

Received February 24, 2005. Accepted in final form December 29, 2005.

Address for correspondence and reprint requests to Dr. Till Sprenger, Department of Neurology, Technische Universität München, Moehlstr. 28, D-81675 Muenchen, Germany; e-mail: sprenger{at}lrz.tu-muenchen.de




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[Abstract] [Full Text] [PDF]


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