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NEUROLOGY 2006;66:1111-1113
© 2006 American Academy of Neurology
Brief Communications

In vivo cholinergic circuit evaluation in frontotemporal and Alzheimer dementias

V. Di Lazzaro, MD, F. Pilato, MD, M. Dileone, MD, E. Saturno, MD, A. Oliviero, MD, C. Marra, MD, A. Daniele, MD, F. Ranieri, MD, G. Gainotti, MD and P. A. Tonali, MD

From the Institute of Neurology (V.D., F.P., M.D., E.S. A.O., C.M., A.D., F.R., G.G., P.A.T.), Università Cattolica, Rome, Italy; Unidad de Neurologia Funcional (A.O.), Hospital Nacional de Paraplejicos, Toledo, Spain; and Fondazione Don C Gnocchi (P.A.T.), Rome, Italy

Address correspondence and reprint requests to Dr. Vincenzo Di Lazzaro, Istituto di Neurologia, Università Cattolica, L.go A. Gemelli 8, 00168 Rome, Italy; e-mail: vdilazzaro{at}rm.unicatt.it

The test of short latency afferent inhibition (SAI) of the motor cortex is helpful in demonstrating dysfunction of central cholinergic circuits in Alzheimer disease (AD). The authors evaluated SAI in 20 patients with frontotemporal dementia (FTD) and compared data with those from 20 patients with AD and 20 controls. SAI was normal in FTD, whereas it was reduced in AD. SAI may represent an additional tool to discriminate FTD from AD.

Supported by the Ministero della Sanità (Programma di ricerca finalizzata 2003-Memoria ed apprendimento motorio dalla fisiopatologia cellulare del danno neuronale sperimentale alle nuove tecniche diagnostiche).

Disclosure: The authors report no conflicts of interest.

Received July 26, 2005. Accepted in final form December 27, 2005.




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