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NEUROLOGY 2006;66:1253-1254
© 2006 American Academy of Neurology
Brief Communications

Annexin V SPECT imaging of phosphatidylserine expression in patients with dementia

Y. Lampl, MD*, M. Lorberboym, MD*, F. G. Blankenberg, MD, M. Sadeh, MD and R. Gilad, MD

From the Departments of Neurology (Y.L., M.S., R.G.) and Nuclear Medicine (M.L.), Edith Wolfson Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; and Department of Radiology (F.G.B.), Stanford University Hospital, Stanford, CA.

Address correspondence and reprint requests to Dr. Mordechai Lorberboym, Department of Nuclear Medicine, Edith Wolfson Medical Center, Holon, 58100, Israel; e-mail: mvlorber{at}zahav.net.il

The authors sought to use radiolabeled annexin V, a marker of phosphatidylserine expression, to image Alzheimer dementia (AD). Four of five patients with AD had multifocal cortical annexin V uptake, whereas all seven non-AD and six control patients had normal SPECT. The mean cortex/cerebellar activity in patients with AD (1.4 ± 0.6) was higher than that of non-AD dementia patients (0.7 ± 0.2; p = 0.02). Radiolabeled annexin V may be useful for imaging AD.

*The first and second authors contributed equally to the manuscript.

Supported in part by Theseus Imaging Corporation, Cambridge, MA.

Disclosure: The authors report no conflicts of interest.

Received September 23, 2005. Accepted in final form January 18, 2006.


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