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NEUROLOGY 2006;66:1255-1257
© 2006 American Academy of Neurology
Brief Communications

Monocyte chemoattractant protein-1 correlates with subcortical brain injury in HIV infection

A. B. Ragin, PhD, Y. Wu, MD, P. Storey, PhD, B. A. Cohen, MD, R. R. Edelman, MD and L. G. Epstein, MD

From the Departments of Radiology (A.B.R., Y.W., P.S., R.R.E.), Neurology (B.A.C., L.G.E.), and Pediatrics (L.G.E.) and The Children's Memorial Research Center, Feinberg School of Medicine, Northwestern University, Chicago, IL; and Department of Radiology, Evanston Northwestern Healthcare (Y.W., P.S., R.R.E.), Evanston, IL.

Various biomarkers have been suggested as associative or predictive of HIV-associated neurocognitive impairment. Plasma levels of monocyte chemoattractant protein 1 (MCP-1), tumor necrosis factor {alpha} (TNF-{alpha}), and hematocrit were evaluated for relationships with diffusion tensor imaging measurements of centrum semiovale, caudate, and putamen. MCP-1 levels correlated with tissue status (mean diffusivity) in all examined regions. Plasma markers were also significantly correlated with anisotropy measurements in centrum semiovale (TNF-{alpha}) and putamen (hematocrit).

The National Institute of Mental Health (MH66705) and the National Institute of Neurological Disorders and Stroke (NS36519 and NS049465) provided funding or support for this study.

Disclosure: The authors report no conflicts of interest.

Received October 7, 2005. Accepted in final form January 18, 2006.

Address reprint requests to Dr. Ann Ragin, Department of Radiology, 676 N. St. Clair St., #1400, Chicago, IL 60611-2927; e-mail: ann-ragin{at}northwestern.edu






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