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NEUROLOGY 2006;66:1267-1269
© 2006 American Academy of Neurology
Brief Communications

White matter damage in neonatal enterovirus meningoencephalitis

M. A. Verboon-Maciolek, MD, PhD, F. Groenendaal, MD, PhD, F. Cowan, MD, PhD, P. Govaert, MD, PhD, A. M. van Loon, PhD and L. S. de Vries, MD, PhD

From the Department of Neonatology (M.A.V.-M., F.G., L.S.d.V.) and Department of Virology, Eijkman Winkler Center for Microbiology, Infectious Disease and Inflammation (A.M.v.L.), University Medical Center, Utrecht, The Netherlands; Department of Pediatrics and Neonatal Medicine, Imperial College, Hammersmith Hospital (F.C.), London, United Kingdom; and Department of Neonatology, Erasmus Medical Center (P.G.), Rotterdam, The Netherlands.

Address correspondence and reprint requests to Dr. Malgorzata A. Verboon-Maciolek, Department of Neonatology, University Medical Center, Lundlaan 6, 3584 EA Utrecht, The Netherlands; e-mail: m.verboon-maciolek{at}wkz.azu.nl

The authors report six neonates with enteroviral meningoencephalitis. Five infants presented with prolonged seizures, and one presented with systemic enteroviral disease. Cranial ultrasonography showed increased echogenicity in the periventricular white matter, and MRI confirmed mild to severe white matter damage in all infants, which looked similar to periventricular leukomalacia. Two infants developed cerebral palsy: one was neurologically suspect at age 18 months, and three were developmentally normal.

Disclosure: The authors report no conflicts of interest.

Received June 20, 2005. Accepted in final form January 16, 2006.




Correspondence:

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Update on article: White matter damage in neonatal enterovirus meningoencephalitis
M. Verboon-Maciolek, et al.
Neurology Online, 10 Mar 2008 [Full text]
Update
M. Verboon-Maciolek, et al.
Neurology Online, 10 Mar 2008 [Full text]

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