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NEUROLOGY 2006;66:1270-1272
© 2006 American Academy of Neurology
Brief Communications

Magnetic source imaging localizes epileptogenic zone in children with tuberous sclerosis complex

J. Y. Wu, MD, W. W. Sutherling, MD, S. Koh, MD, N. Salamon, MD, R. Jonas, MD, S. Yudovin, RN, MN, PNP, R. Sankar, MD, PhD, W. D. Shields, MD and G. W. Mathern, MD

From the Division of Pediatric Neurology (J.Y.W., S.K., R.J., S.Y., R.S., W.D.S.); Division of Neuroradiology (N.S.); Division of Neurosurgery, The Brain Research Institute, and The Mental Retardation Research Center (G.W.M.), David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA; and Epilepsy and Brain Mapping Program, Huntington Hospital (W.W.S.), Pasadena, CA.

Address correspondence and reprint requests to Dr. Joyce Y. Wu, 22-474 MDCC, Division of Pediatric Neurology, Mattel Children’s Hospital at UCLA, David Geffen School of Medicine, Los Angeles, CA 90095-1752; e-mail: joycewu{at}mednet.ucla.edu

The authors assessed whether magnetoencephalography/magnetic source imaging (MEG/MSI) identified epileptogenic zones in patients with tuberous sclerosis complex (TSC). In six TSC children with focal seizures, ictal video-EEG predicted the region of resection with 56% sensitivity, 80% specificity, and 77% accuracy (p = 0.02), whereas interictal MEG/MSI fared better (100%, 94%, and 95%, respectively; p < 0.0001). Interictal MEG/MSI seems to identify epileptogenic zones more accurately in children with TSC and focal intractable epilepsy.

Supported by NIH grants K23 NS051637 to J.Y.W., R01 NS020806 to W.W.S., R01 NS046516 to R.S., and R01 NS038992 and P01 NS002808 to G.W.M.

Disclosure: The authors report no conflicts of interest.

Received August 11, 2005. Accepted in final form January 18, 2006.




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