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NEUROLOGY 2006;66:1273-1275
© 2006 American Academy of Neurology
Brief Communications

The ICAM-1 E469K gene polymorphism is a risk factor for spontaneous cervical artery dissection

M. Longoni, MD, C. Grond-Ginsbach, PhD, A. J. Grau, MD, J. Genius, MD, S. Debette, MD, M. Schwaninger, PhD, MD, C. Ferrarese, PhD, MD and C. Lichy, MD

From the Department of Neurology (M.L., C.F.), University of Milano-Bicocca, Monza, Monza, Italy; Department of Neurology (M.L., C.G.-G., J.G., S.D., M.S., C.L.), University of Heidelberg, Heidelberg, Germany; Department of Neurology (S.D.), Lille University Hospital, Lille, France; and Department of Neurology (A.J.G.), Hospital of Ludwigshafen, Ludwigshafen, Germany.

Address correspondence and reprint requests to Dr. Marco Longoni, Department of Neurology, HS Gerardo, via Donizetti 106, 20052 Monza, Italy; e-mail: longonimarco{at}hotmail.com

In a primary study on proinflammatory genetic profiles in stroke, the authors found the E469K polymorphism of the intercellular adhesion molecule 1 (ICAM-1) highly represented in the subgroup with spontaneous cervical artery dissection (sCAD). They further investigated the same genetic variant in a second group of 65 patients with sCAD. An association between sCAD and EE genotype was confirmed (odds ratio 3.16; p < 0.01), indicating that a proinflammatory predisposition is a risk factor for sCAD.

Disclosure: The authors report no conflicts of interest.

Received July 6, 2005. Accepted in final form January 18, 2006.


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