| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
From the Department of Neurology and Alzheimer Center (C.C., W.M.v.d.F., P.S.) and Department of Radiology and Image Analysis Center (J.D.S., F.B.), VU University Medical Center, Amsterdam, the Netherlands; and Department of Neurology and Stroke Unit (C.C., D.L.), Lille University Hospital, France.
Address correspondence and reprint requests to Prof. P. Scheltens, Department of Neurology and Alzheimer Center, Vrije Universiteit Medical Center, PO Box 7057, 1007 MB, Amsterdam, the Netherlands; e-mail: p.scheltens{at}vumc.nl
Objective: To determine prevalence and severity of microbleeds (MBs) in a large cohort of patients attending a memory clinic.
Methods: The authors consecutively included patients attending their memory clinic between January 2002 and April 2005. They analyzed prevalence and number of MBs according to demographic, diagnostic, and MRI data.
Results: The authors included 772 patients (53% men, age 66 ± 11). One hundred twenty-seven patients (17%) exhibited at least one MB. The prevalence differed according to diagnostic groups (p < 0.0001): Sixty-five percent of patients with vascular dementia exhibited MBs vs 18% of Alzheimer disease patients, 20% of mild cognitive impairment patients, and 10% of patients with subjective complaints. The presence of MBs was associated with age, white matter hyperintensities, lacunar infarcts, and infarcts.
Conclusion: The prevalence of microbleeds (MBs) in a large cohort of patients attending a memory clinic is higher than previously described in community samples and lower than reported in stroke patients. This finding of a relatively high proportion of MBs in Alzheimer disease and mild cognitive impairment provides further evidence for the involvement of vascular factors in neurodegenerative diseases such as Alzheimer disease.
Dr. C. Cordonnier received a grant for this study from the Lille University Hospital, EA 2691 (University Lille II), France, and Stichting Alzheimer and Neuropsychiatrie Foundation, Amsterdam, the Netherlands.
Disclosure: The authors report no conflicts of interest
Received October 4, 2005. Accepted in final form January 20, 2006.
This article has been cited by other articles:
|
|
 |
|
  J. D.C. Goos, M.I. Kester, F. Barkhof, M. Klein, M. A. Blankenstein, P. Scheltens, and W. M. van der Flier Patients With Alzheimer Disease With Multiple Microbleeds: Relation With Cerebrospinal Fluid Biomarkers and Cognition Stroke, November 1, 2009; 40(11): 3455 - 3460. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. E. Smith and S. M. Greenberg {beta}-Amyloid, Blood Vessels, and Brain Function Stroke, July 1, 2009; 40(7): 2601 - 2606. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. S. Staekenborg, E. L.G.E. Koedam, W. J.P. Henneman, P. Stokman, F. Barkhof, P. Scheltens, and W. M. van der Flier Progression of Mild Cognitive Impairment to Dementia: Contribution of Cerebrovascular Disease Compared With Medial Temporal Lobe Atrophy Stroke, April 1, 2009; 40(4): 1269 - 1274. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R.N.K. Nandigam, A. Viswanathan, P. Delgado, M.E. Skehan, E.E. Smith, J. Rosand, S.M. Greenberg, and B.C. Dickerson MR Imaging Detection of Cerebral Microbleeds: Effect of Susceptibility-Weighted Imaging, Section Thickness, and Field Strength AJNR Am. J. Neuroradiol., February 1, 2009; 30(2): 338 - 343. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. J.P. Henneman, J. D. Sluimer, C. Cordonnier, M. M.E. Baak, P. Scheltens, F. Barkhof, and W. M. van der Flier MRI Biomarkers of Vascular Damage and Atrophy Predicting Mortality in a Memory Clinic Population Stroke, February 1, 2009; 40(2): 492 - 498. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Yakushiji, M. Nishiyama, S. Yakushiji, T. Hirotsu, A. Uchino, J. Nakajima, M. Eriguchi, Y. Nanri, M. Hara, E. Horikawa, et al. Brain Microbleeds and Global Cognitive Function in Adults Without Neurological Disorder Stroke, December 1, 2008; 39(12): 3323 - 3328. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S Sveinbjornsdottir, S Sigurdsson, T Aspelund, O Kjartansson, G Eiriksdottir, B Valtysdottir, O L Lopez, M A van Buchem, P V Jonsson, V Gudnason, et al. Cerebral microbleeds in the population based AGES-Reykjavik study: prevalence and location J. Neurol. Neurosurg. Psychiatry, September 1, 2008; 79(9): 1002 - 1006. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. Pettersen, G. Sathiyamoorthy, F.-Q. Gao, G. Szilagyi, N. K. Nadkarni, P. St George-Hyslop, E. Rogaeva, and S. E. Black Microbleed Topography, Leukoaraiosis, and Cognition in Probable Alzheimer Disease From the Sunnybrook Dementia Study Arch Neurol, June 1, 2008; 65(6): 790 - 795. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. W. Vernooij, A. van der Lugt, M. A. Ikram, P. A. Wielopolski, W. J. Niessen, A. Hofman, G. P. Krestin, and M.M.B. Breteler Prevalence and risk factors of cerebral microbleeds: The Rotterdam Scan Study Neurology, April 1, 2008; 70(14): 1208 - 1214. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S MILLS, J CAIN, N PURANDARE, and A JACKSON Biomarkers of cerebrovascular disease in dementia Br. J. Radiol., December 1, 2007; 80(Special_Issue_2): S128 - S145. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Cordonnier, R. Al-Shahi Salman, and J. Wardlaw Spontaneous brain microbleeds: systematic review, subgroup analyses and standards for study design and reporting Brain, August 1, 2007; 130(8): 1988 - 2003. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Won Seo, B. Hwa Lee, E.-J. Kim, J. Chin, Y. Sun Cho, U. Yoon, and D. L. Na Clinical Significance of Microbleeds in Subcortical Vascular Dementia Stroke, June 1, 2007; 38(6): 1949 - 1951. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Schneider Brain Microbleeds and Cognitive Function Stroke, June 1, 2007; 38(6): 1730 - 1731. [Full Text] [PDF]
|
|
|
|
|
|
C. Cordonnier, H. Henon, P. Derambure, F. Pasquier, and D. Leys Early epileptic seizures after stroke are associated with increased risk of new-onset dementia J. Neurol. Neurosurg. Psychiatry, May 1, 2007; 78(5): 514 - 516. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. S. Jeret, C . Cordonnier, W .M. van der Flier, J .D. Sluimer, F . Barkhof, and P . Scheltens Prevalence and severity of microbleeds in a memory clinic setting Neurology, January 30, 2007; 68(5): 391 - 391. [Full Text] [PDF]
|
|
Read all Correspondence
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
