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 Volume 66, Number 9, May 9, 2006
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NEUROLOGY 2006;66:1432-1434
© 2006 American Academy of Neurology
Brief Communications

Voglibose inhibits postprandial hypotension in neurologic disorders and elderly people

Takahiro Maruta, MD, PhD, Kiyonobu Komai, MD, PhD, Masaharu Takamori, MD, PhD and Masahito Yamada, MD, PhD

From the Department of Neurology and Neurobiology of Aging, Graduate School of Medicine, Kanazawa University (T.M., K.K., M.Y.), and the Department of Neurology, Neurological Center, Kanazawa Nishi Hospital (T.M., M.T.), Japan.

Address correspondence and reprint requests to Dr. Takahiro Maruta, Department of Neurology and Neurobiology of Aging, Graduate School of Medicine, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8640, Japan; e-mail: ryu_taiga{at}ybb.ne.jp

The authors examined blood pressure, glucose, insulin, and neurotensin before and after intake of 75 g glucose with or without voglibose in 28 neurologic patients and 20 healthy controls. Voglibose significantly prevented hypotension and neurotensin increment after glucose intake and had no influence on glucose or insulin increment. These results suggest that voglibose benefits postprandial hypotension.

Disclosure: The authors report no conflicts of interest.

Received July 26, 2005. Accepted in final form January 31, 2006.




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