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Variable benefit in neuropsychological function in HIV-infected HAART-treated patients

From the Faculty of Medicine (L.A.J.C.), St. Vincent’s Clinical School, University of New South Wales, Sydney, Australia; School of Psychology (P.M.), LaTrobe University, Melbourne, Australia; Departments of Neurology and HIV Medicine (B.J.B.), St. Vincent’s Hospital, Sydney, Australia.

Address correspondence and reprint requests to Dr. Lucette Cysique, HNRC, 150 West Washington Street, 2nd Floor, San Diego, CA 92103; e-mail: lcysique{at}ucsd.edu

The authors examined cognitive performance change in 101 individuals with advanced HIV infection on highly active antiretroviral therapy (HAART), using standard neuropsychological testing in three visits, over a 27-month-period. Cognitive performance stabilized in a majority of HIV+ participants over time. A neuroactive HAART regimen was associated with neuropsychological improvement. Decline occurred in a minority with lower nadir CD4. The current CD4 count and plasma viral load were not associated with cognitive change.

Disclosure: The authors report no conflicts of interest.

Received October 18, 2005. Accepted in final form January 23, 2006.

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