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NEUROLOGY 2006;67:131-133
© 2006 American Academy of Neurology
Brief Communications

Glucose utilization in the inferior cerebellar vermis and ocular myoclonus

Y. Yakushiji, MD, R. Otsubo, MD, T. Hayashi, MD, K. Fukuchi, MD, N. Yamada, MD, Y. Hasegawa, MD and K. Minematsu, MD

From the Cerebrovascular Division, Department of Medicine (Y.Y., R.O., Y.H., K.M.), Department of Investigative Radiology, Advanced Medical Engineering Center, Research Institute (T.H.), and Department of Radiology and Nuclear Medicine (T.H., K.F., N.Y.), National Cardiovascular Center, Osaka, Japan. Dr. Yakushiji is currently with the Division of Neurology, Department of Internal Medicine, Saga University Faculty of Medicine, Saga, Japan.

Address correspondence and reprint requests to Dr. Yusuke Yakushiji, Division of Neurology, Department of Internal Medicine, Saga University Faculty of Medicine, 5-1-1 Nabeshima, Saga 849-8501, Japan; e-mail: yakushiz{at}tg7.so-net.ne.jp

In a patient with symptomatic ocular myoclonus, the authors observed the regional cerebral metabolic rate of glucose use (rCMRGlu) before and after successful treatment with clonazepam. Even after the symptoms resolved, the rCMRGlu in the hypertrophic olive increased persistently, whereas that in the inferior cerebellar vermis contralateral to the hypertrophic olive decreased. The inferior cerebellar vermis, belonging to the vestibulocerebellar system, may be associated with the generation of symptomatic ocular myoclonus.

Commentary, see page 3

Supported in part by the Research Grant for Cardiovascular Diseases (15C-1 and 18C-5) from the Ministry of Health, Labor and Welfare, Japan.

Disclosure: The authors report no conflicts of interest.

Received December 27, 2005. Accepted in final form March 29, 2006.




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