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NEUROLOGY 2006;67:134-136
© 2006 American Academy of Neurology
Brief Communications

Hippocampal abnormalities and seizure recurrence after antiepileptic drug withdrawal

T.A.M. Cardoso, MD, PhD*, A. C. Coan, MD*, E. Kobayashi, MD, PhD, C. A.M. Guerreiro, MD, PhD, L. M. Li, MD, PhD and F. Cendes, MD, PhD

From the Department of Neurology, FCM, State University of Campinas–UNICAMP, Brazil.

Address correspondence and reprint requests to Dr. Fernando Cendes, Departamento de Neurologia, Faculdade de Ciências Médicas–UNICAMP, Cidade Universitária Zeferino Vaz, Campinas SP, Brazil, CEP 13083-970; e-mail: fcendes{at}unicamp.br

The authors performed hippocampal volumetry and T2 relaxometry in 84 consecutive patients with partial epilepsy from a protocol for antiepileptic drug (AED) withdrawal after at least 2 years of seizure control. Seizure recurrence after AED withdrawal was more frequent among patients with hippocampal atrophy and abnormal hippocampal T2 signal.

Editorial, see page 12

Additional material related to this article can be found on the Neurology Web site. Go to www.neurology.org and scroll down the Table of Contents for the July 11 issue to find the title link for this article.

*Both authors contributed equally to data analysis and manuscript preparation.

Supported by FAPESP (Fundação de Amparo à Pesquisa do Estado de São Paulo, scholarship number 03/01528-7) and CNPq (Conselho Nacional de Desenvolvimento Científico e Tecnológico, scholarship number 131012/2005-3).

Disclosure: The authors report no conflicts of interest.

Received September 19, 2005. Accepted in final form March 17, 2006.


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