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NEUROLOGY 2006;67:140-142
© 2006 American Academy of Neurology
Brief Communications

Sleep apnea in patients with myasthenia gravis

M. W. Nicolle, MD, FRCPC, DPhil, S. Rask, BSc, W. J. Koopman, RN, MScN, C.F.P. George, MD, FRCPC, DABSM, J. Adams, MD, FRCPC, MSc and S. Wiebe, MD, FRCPC, MSc

From the Division of Neurology (M.W.N., S.R., W.J.K.), Department of Clinical Neurological Sciences and Division of Respirology (C.F.P.G.), Department of Medicine, University of Western Ontario, London, Ontario; the Department of Medicine (J.A.), Pacific Parkinson's Research Centre, University of British Columbia, Vancouver, British Columbia; and the Division of Neurology (S.W.), Department of Medicine, University of Calgary, Calgary, Alberta, Canada.

Address correspondence and reprints requests to Dr. Michael W. Nicolle, Department of Clinical Neurological Sciences, London Health Sciences Centre, 339 Windermere Road, London, Ontario, Canada N6A 5A5; e-mail: mnicolle{at}uwo.ca

To assess the prevalence of obstructive sleep apnea (OSA) in myasthenia gravis, the authors identified patients at risk of OSA using the multivariable apnea prediction index. OSA was diagnosed with polysomnography. The prevalence of OSA was 36% compared to an expected prevalence of 15 to 20% in the general population. When including the presence of daytime sleepiness (OSA syndrome), the prevalence was 11% compared to 3% in the general population.

Additional material related to this article can be found on the Neurology Web site. Go to www.neurology.org and scroll down the Table of Contents for the July 11 issue to find the title link for this article.

Sara Rask was awarded a Henry R. Viets Medical Student Research Fellowship award by the Myasthenia Gravis Foundation of America (2003) for this project.

Disclosure: The authors report no conflicts of interest.

Received April 21, 2005. Accepted in final form March 13, 2006.






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