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Hypothalamic stimulation for intractable cluster headache: Long-term experience

From the Istituto Nazionale Neurologico Carlo Besta, Milano, Italy.

Address correspondence and reprint requests to Dr. Massimo Leone, Department of Neurology and Headache Centre, Istituto Nazionale Neurologico "Carlo Besta," via Celoria 11, 20133 Milano, Italy; e-mail: leone{at}istituto-besta.it

The authors report long-term results of continuous hypothalamic stimulation in 16 chronic drug-refractory patients with cluster headache (CH). At a mean follow-up of 23 months, 13 patients are persistently pain-free or almost pain-free, and the other 3 are improved. There are no persistent side effects. Hypothalamic stimulation is an effective, safe, and well-tolerated alternative to surgery for chronic patients with drug-refractory CH.

Additional material related to this article can be found on the Neurology Web site. Go to www.neurology.org and scroll down the Table of Contents for the July 11 issue to find the title link for this article.

Disclosure: The authors report no conflicts of interest.

Received November 8, 2005. Accepted in final form March 17, 2006.

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