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 Volume 67, Number 1, July 11, 2006
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NEUROLOGY 2006;67:159-160
© 2006 American Academy of Neurology
Brief Communications

Diffuse cerebral vasoconstriction (Call–Fleming syndrome) and stroke associated with antidepressants

Olga Noskin, MD*, Elham Jafarimojarrad, MD*, Richard B. Libman, MD, FRCPC and Jeffrey L. Nelson, MD

From the Department of Neurology (O.N., R.B.L.), Long Island Jewish Medical Center, New Hyde Park, NY; and Department of Neurology (E.J., J.L.N.), North Shore University Hospital, Manhasset, NY.

Address correspondence and reprint requests to Dr. Richard B. Libman, The Department of Neurology, Long Island Jewish Medical Center, The Long Island Campus for the Albert Einstein College of Medicine, New Hyde Park, New York 11040; e-mail: rlibman{at}lij.edu

Call–Fleming syndrome is a reversible segmental vasoconstriction of cerebral arteries manifested by a "thunderclap" headache and focal neurologic symptoms. Although of unknown etiology, it has been reported in association with vasoactive sympathomimetic drugs. The authors report Call–Fleming syndrome in two patients with history of antidepressant use. Although the association is hypothetical, the authors suggest consideration of Call–Fleming syndrome in patients presenting with headache, focal deficits, and evidence of cerebral ischemia during antidepressant use.

*These authors have contributed equally to the final submission.

Disclosure: The authors report no conflicts of interest.

Received December 12, 2005. Accepted in final form March 14, 2006.


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L. H. Calabrese, D. W. Dodick, T. J. Schwedt, and A. B. Singhal
Narrative Review: Reversible Cerebral Vasoconstriction Syndromes
Ann Intern Med, January 2, 2007; 146(1): 34 - 44.
[Abstract] [Full Text] [PDF]


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