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NEUROLOGY 2006;67:1844-1845
© 2006 American Academy of Neurology
Brief Communications

Acute hypothalamic stimulation and ongoing cluster headache attacks

M. Leone, MD, A. Franzini, MD, G. Broggi, MD, E. Mea, MD, A. Proietti Cecchini, MD and G. Bussone, MD

From the Department of Neurology and Headache Centre (M.L., E.M., A.P.C., G.B.) and Department of Neurosurgery (A.F., G.B.), Istituto Nazionale Neurologico Carlo Besta, Milano, Italy.

Address correspondence and reprint requests to Dr. Massimo Leone, Department of Neurology and Headache Centre, Istituto Nazionale Neurologico ‘Carlo Besta,' via Celoria 11, 20133 Milano, Italy; e-mail: leone{at}istituto-besta.it

Long-term hypothalamic stimulation is effective in improving drug-resistant chronic cluster headache (CH). We assessed acute hypothalamic stimulation to resolve ongoing CH attacks in 16 patients implanted to prevent chronic CH, investigating 136 attacks. A pain intensity reduction of ≥50% occurred in 25 of 108 evaluable attacks (23.1%). Acute hypothalamic stimulation is not effective in resolving ongoing CH attacks, suggesting that hypothalamic stimulation acts by complex mechanisms in CH prevention.

Additional material related to this article can be found on the Neurology Web site. Go to www.neurology.org and scroll down the Table of Contents for the November 28 issue to find the title link for this article.

Disclosure: The authors report no conflicts of interest.

Received April 25, 2006. Accepted in final form August 22, 2006.

Commentary, see page 1735


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