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NEUROLOGY 2006;67:1846-1848
© 2006 American Academy of Neurology
Brief Communications

Prediction of thrombolytic efficacy in acute ischemic stroke using thin-section noncontrast CT

E. Y. Kim, MD, J. H. Heo, MD, S-K Lee, MD, D. J. Kim, MD, S-H Suh, MD, J. Kim, MD and D. I. Kim, MD

From the Department of Radiology, Research Institute of Radiologic Science (E.Y.K., S-K.L., D.J.K., S-H.S., J.K., D.I.K.) and Department of Neurology (J.H.H.), Yonsei University College of Medicine, Seoul, Korea.

Address correspondence and reprint requests to Dr. Eung Y. Kim, Department of Radiology and Research Institute of Radiological Sciences, Yonsei University College of Medicine, 134 Shinchon-dong, Seodaemun-gu, Seoul 120-752, Korea; e-mail: eungykim{at}yumc.yonsei.ac.kr

Thin-section noncontrast CT (NCT) can detect thrombi in large arteries and can provide a measure of thrombus composition based on Hounsfield Units (HU). A study using polyethylene tubes as a model of intracranial arteries concluded that the HUs of platelet-rich thrombi are lower than those of erythrocyte-rich thrombi. Thrombus HUs were measured by NCT in 34 patients with acute ischemic stroke before thrombolysis. Thrombi with lower HU counts were resistant to thrombolytics.

Disclosure: The authors report no conflicts of interest.

Received April 5, 2006. Accepted in final form July 28, 2006.


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