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Anatomical correlates of early mutism in progressive nonfluent aphasia

From the Department of Neurology, University of California at San Francisco.

Address correspondence and reprint requests to Dr Gorno-Tempini, UCSF Department of Neurology, Memory and Aging Center, 350 Parnassus Ave., Suite 800, Box 1207, San Francisco, CA 94143-1207; e-mail: marilu{at}memory.ucsf.edu

Patients with progressive nonfluent aphasia (PNFA) can become mute early in the course of the disease. Voxel-based morphometry showed that PNFA is associated with left anterior insula and inferior frontal atrophy. In PNFA with early mutism, volume loss was more prominent in the pars opercularis and extended into the left basal ganglia. Damage to the network of brain regions involved in both coordination and execution of speech causes mutism in PNFA.

Additional material related to this article can be found on the Neurology Web site. Go to www.neurology.org and scroll down the Table of Contents for the November 28 issue to find the title link for this article.

Editorial, see page 1738

See also page 1752

This article was previously published in electronic format as an Expedited E-Pub on August 23, 2006, at www.neurology.com.

Supported by the National Institute of Neurological Disorders and Stroke (R01 NS050915), the State of California (DHS 04-35516), the National Institute on Aging (P50 AG03006, P01 AG019724), the John Douglas French Alzheimer’s Foundation, the McBean Foundation, the Sandler Foundation, the AD Research Center of California (03-75271 DHS/ADP/ARCC), the Larry Hillblom Foundation (grant 2002/2F), and the Koret Foundation (grant 99-0102).

Disclosure: The authors report no conflicts of interest.

Received January 17, 2006. Accepted in final form June 19, 2006.

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