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Reduction of optic nerve fibers in patients with Alzheimer disease identified by laser imaging

From the Department of Ophthalmology (H.V.D.-M., J.Y.-F.K., S.C.), University of Auckland; Older People’s Health (H.B.), Auckland City Hospital; and Department of Medicine (G.G.), University of Auckland, Auckland, New Zealand.

Address correspondence and reprint requests to Helen V. Danesh-Meyer, FRANZCO, Department of Ophthalmology, University of Auckland, Auckland. New Zealand; e-mail: h.daneshmeyer{at}auckland.ac.nz

In this case-control study, we compared the optic nerves (ONs) by clinical examination and scanning laser ophthalmoscopy (SLO) of 40 patients with Alzheimer disease (AD) and 50 controls. There was a reduction in the number of ON fibers in patients with AD, with a threefold greater odds ratio for a larger optic cup-to-disc ratio in patients with AD.

Additional material related to this article can be found on the Neurology Web site. Go to www.neurology.org and scroll down the Table of Contents for the November 28 issue to find the title link for this article.

Supported by an unrestricted research fund from Alcon Laboratories Ltd.

Disclosure: The authors report no conflicts of interest.

Received March 6, 2006. Accepted in final form August 13, 2006.

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