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NEUROLOGY 2006;67:1867-1869
© 2006 American Academy of Neurology
Brief Communications

Diminished somatostatin gene expression in individuals with HIV and major depressive disorder

I. P. Everall, FRCPsych, FRCPath, PhD, S. Salaria, BSc, MSc, J. H. Atkinson, MD, C. Young, PhD, J. Corbeil, PhD, I. Grant, MD, E. Masliah, MD and from the HNRC*

From the Departments of Psychiatry (I.P.E., J.H.A., I.G.) and Neuroscience (E.M.), University of California, San Diego (S.S., C.Y.); and Department of Medical Genomics (J.C.), Laval University, Quebec, Canada.

Address correspondence and reprint requests to Dr Everall, Department of Psychiatry, 9500 Gilman Dr., La Jolla CA 92093-0603; e-mail: ieverall{at}ucsd.edu

In analyzing the expression of 15 candidate genes for HIV encephalitis (HIVE) by the presence or absence of major depressive disorder (MDD), we noted significant reductions in the expression of four cytoskeletal genes and somatostatin. Whereas disruption of cytoskeletal genes has been noted in HIVE, dysregulation of somatostatin has not, indicating that dysregulation of somatostatin is part of the molecular pathologic process of MDD in the setting of HIV.

*See the appendix for a complete list of Group members.

J.C. is a holder of a Canadian Research Chair and acknowledges the support of the Center for AIDS Research Genomics Core Laboratory, University of California, San Diego. The HIV Neurobehavioral Research Center (HNRC) is supported by center award MH 62512 from NIMH.

Disclosure: The authors report no conflicts of interest.

Received April 1, 2005. Accepted in final form July 24, 2006.






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