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NEUROLOGY 2006;67:1887-1889
© 2006 American Academy of Neurology
Brief Communications

Pregnancy and birth outcomes in women with facioscapulohumeral muscular dystrophy

E. Ciafaloni, MD, E. K. Pressman, MD, A. M. Loi, MD, A. M. Smirnow, BSc, D. J. Guntrum, MS, RPN, N. Dilek, MS and R. Tawil, MD

From the Departments of Neurology (E.C., R.T., D.J.G., A.M.S., N.D.) and Obstetrics and Gynecology (E.K.P., A.M.L.), University of Rochester, Rochester, NY.

Address correspondence and reprint requests to: Dr. Emma Ciafaloni, Department of Neurology, University of Rochester, 601 Elmwood Avenue, Box 673, Rochester, NY 14642; e-mail: Emma_Ciafaloni{at}urmc.rochester.edu

Obstetric risk in facioscapulohumeral muscular dystrophy (FSHD) is not known. We surveyed 38 women with FSHD reporting 105 gestations and 78 live births. Review of medical records showed that pregnancy outcomes were generally favorable. The rates for low birth weight and total operative deliveries were statistically higher than the national rates in the general population. Worsening of FSHD was reported in 24% of gestations and did not usually resolve after delivery.

Supported by the FSH Society, Inc., and used The National Registry of Myotonic Dystrophy and Facioscapulohumeral Muscular Dystrophy (FSHD) Patients and Family Members at the University of Rochester (NIH Contract N01-AR-5-2274). This work comes from the University of Rochester Senator Paul Wellstone Muscular Dystrophy Cooperative Research Center (grant U54NS48843-03).

Disclosure: The authors report no conflicts of interest.

Received May 1, 2006. Accepted in final form August 11, 2006.






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