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Two randomized vitamin D trials in ambulatory patients on anticonvulsants

Impact on bone

From the Adult and Pediatric Epilepsy Program, Department of Pediatrics (M.A.M., A.C.R.), Division of Neurology (B.Y., M.A.M., R.S.) and Calcium Metabolism and Osteoporosis Program (L.D., G.E.-H.F.) Department of Internal Medicine; American University of Beirut Medical Center, Beirut, Lebanon.

Address correspondence and reprint requests to Dr. Mohamad A. Mikati, Adult and Pediatric Epilepsy Program, Department of Pediatrics, American University of Beirut Medical Center, Beirut, Lebanon; e-mail: mamikati{at}aub.edu.lb, or to Dr. Ghada El-Hajj Fuleihan, Calcium Metabolism and Osteoporosis Program, American University of Beirut Medical Center, Beirut, Lebanon; e-mail: gf01{at}aub.edu.lb

Objective: To investigate the effects of two doses of vitamin D given over 1 year on bone density in ambulatory patients on long-term antiepileptic drug (AED) therapy.

Methods: We conducted two parallel, randomized, controlled trials in 72 adults (18 to 54 years old) and 78 children and adolescents (10 to 18 years) on long-term AED therapy. They received either low-dose vitamin D 400 IU/day or high-dose vitamin D 4,000 IU/day (adults) and 2,000 IU/day (children/adolescents). Bone mineral density (BMD) was measured using dual-energy x-ray absorptiometry.

Results: In adults, baseline BMD was lower than that of age- and gender-matched controls vs either a Western or an ethnically identical population. After 1 year, there were significant increases in BMD at all skeletal sites compared to baseline in the high-, but not in the low-dose treatment group. However, BMD at 1 year remained below normal. In children, baseline BMD was normal vs age- and gender-matched controls and showed significant and comparable increases in both treatment groups.

Conclusions: In ambulatory adults on antiepileptic drugs, high-dose vitamin D therapy substantially increased bone mineral density at several skeletal sites. In children, both doses resulted in comparable increases in bone mass.

Supported by an institutional grant from the American University of Beirut and by the Lebanese National Council for Scientific Research.

Disclosure: The authors report no conflicts of interest.

Received January 17, 2006. Accepted in final form August 17, 2006.

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