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 Volume 67, Number 11, December 12, 2006
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NEUROLOGY 2006;67:2036-2038
© 2006 American Academy of Neurology
Brief Communications

Unexplained neurologic symptoms: An fMRI study of sensory conversion disorder

Omar Ghaffar, MD, MSc, W. Richard Staines, PhD and Anthony Feinstein, MD, MPhil, FRCP

From the Neuropsychiatry Division, Departments of Psychiatry (O.G., A.F.) and Neurology (W.R.S.), Sunnybrook Health Sciences Centre, University of Toronto; and Canada Research Chair in Sensorimotor Control, Department of Kinesiology (W.R.S.), University of Waterloo, Canada.

Address correspondence and reprint requests to Dr. Anthony Feinstein, Department of Psychiatry, Sunnybrook Health Sciences Centre, FG08-2075 Bayview Avenue, Toronto, ON M4N 3M5, Canada; e-mail: ant.feinstein{at}utoronto.ca

We investigated three subjects with unexplained sensory loss meeting criteria for conversion disorder using brain fMRI during unilateral and bilateral vibrotactile stimulation. In each subject, stimulation of the affected limb did not produce activation of the contralateral primary somatosensory (S1) region, whereas bilateral limb stimulation did. These findings implicate selective alterations in primary sensorimotor cortex activity in conversion disorder, and may also reconcile the discordant results of previous studies.

Additional material related to this article can be found on the Neurology Web site. Go to www.neurology.org and scroll down the Table of Contents for the December 12 issue to find the title link for this article.

Disclosure: Funded by a resident research grant from the Physicians’ Services Incorporated Foundation. Dr. Staines et al. hold the patent for the somatosensory stimulation device used in this study.

Received November 17, 2005. Accepted in final form August 1, 2006.

Editorial, see page 1914


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