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NEUROLOGY 2006;67:2039-2041
© 2006 American Academy of Neurology
Brief Communications

Hormone effects on fMRI and cognitive measures of encoding: Importance of hormone preparation

C. E. Gleason, PhD, T. W. Schmitz, BS, T. Hess, MS, R. L. Koscik, PhD, M. A. Trivedi, PhD, M. L. Ries, PhD, C. M. Carlsson, MD, MS, M. A. Sager, MD, S. Asthana, MD and S. C. Johnson, PhD

From the Section of Geriatrics and Gerontology (C.E.G., T.W.S., M.A.T., M.L.R., C.M.C., M.A.S., S.A., S.C.J.), Department of Medicine, and Department of Biostatistics and Medical Informatics (T.H., R.L.K.), University of Wisconsin, and Geriatric Research, Education, and Clinical Center (C.E.G., T.W.S., M.A.T., M.L.R., C.M.C., S.A., S.C.J.), William S. Middleton Memorial Veterans Hospital, Madison, WI.

Address correspondence and reprint requests to Dr Gleason, Section of Geriatrics, Department of Medicine, University of Wisconsin, 2870 University Ave., Suite 106, Madison, WI 53705; e-mail: address: ceg{at}medicine.wisc.edu

We compared fMRI and cognitive data from nine hormone therapy (HT)–naive women with data from women exposed to either opposed conjugated equine estrogens (CEE) (n = 10) or opposed estradiol (n = 4). Exposure to either form of HT was associated with healthier fMRI response; however, CEE-exposed women exhibited poorer memory performance than either HT-naive or estradiol-exposed subjects. These preliminary findings emphasize the need to characterize differential neural effects of various HTs.

Additional material related to this article can be found on the Neurology Web site. Go to www.neurology.org and scroll down the Table of Contents for the December 12 issue to find the title link for this article.

Supported by grants K23 AG024302 (C.E.G.) and RO1 AG21155 (S.C.J.) (GRECC manuscript no.2006-11).

Disclosure: The authors report no conflicts of interest.

Received August 22, 2005. Accepted in final form August 3, 2006.






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