NEUROLOGY 2006;67:2063-2065
© 2006 American Academy of Neurology
Brief Communications
High seroprevalence of Epstein–Barr virus in children with multiple sclerosis
D. Pohl, MD,
B. Krone, PhD, MD,
K. Rostasy, MD,
E. Kahler, PhD,
E. Brunner, PhD,
M. Lehnert,
H. -J. Wagner, MD,
J. Gärtner, MD and
F. Hanefeld, MD
From Brauweg 19, Goettingen, Germany (D.P.); Department of Pediatrics and Pediatric Neurology, Georg August University Goettingen, Germany (K.R., J.G., F.H.); Department of Virology, Georg August University Goettingen, Germany (B.K.); Department of Medical Statistics, Georg August University Goettingen, Germany (E.K., E.B.); and Department of Pediatrics, University of Giessen, Germany (H-J.W.).
Address correspondence and reprint requests to Daniela Pohl, Brauweg 19, 37073 Goettingen, Germany; e-mail: dani.pohl{at}gmx.net
We studied seroprevalence and concentrations of Epstein–Barr virus (EBV) antibodies in 147 pediatric patients with multiple sclerosis (MS) and paired controls. The children with MS showed a near-complete seropositivity for EBV antibody against virus capsid antigen (98.6% vs 72.1% in controls, p = 0.001) but did not display serologic evidence for a recent EBV infection. EBV antibody concentrations of pediatric patients with MS were significantly higher vs controls.
Additional material related to this article can be found on the Neurology Web site. Go to www.neurology.org and scroll down the Table of Contents for the December 12 issue to find the title link for this article.
This work was supported by a grant of the Hertie-Stiftung (GHS 191/00).
Disclosure: The authors report no conflicts of interest.
Received May 19, 2006. Accepted in final form August 8, 2006.
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