Neurology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Data Supplement
Right arrow Correspondence:
Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Niermeijer, J.M.F.
Right arrow Articles by Notermans, N. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Niermeijer, J.M.F.
Right arrow Articles by Notermans, N. C.
Related Collections
Right arrow All Immunology
Right arrow Autoimmune diseases
Right arrow Peripheral neuropathy
Right arrow All Clinical trials
Right arrow Clinical trials Observational study (Cohort, Case control)
NEUROLOGY 2006;67:2076-2079
© 2006 American Academy of Neurology
Brief Communications

Neurologic and hematologic response to fludarabine treatment in IgM MGUS polyneuropathy

J.M.F. Niermeijer, MD, M. Eurelings, MD, PhD, H. Lokhorst, MD, PhD, H. Franssen, MD, PhD, R. Fijnheer, MD, J. H.J. Wokke, MD, PhD and N. C. Notermans, MD, PhD

From the Departments of Neurology and the Rudolf Magnus Institute for Neuroscience (J.M.F.N., M.E., J.H.J.W. N.C.N.), Clinical Neurophysiology (H.F.), and Hematology (H.L., R.F.), University Medical Center Utrecht, the Netherlands.

Address correspondence and reprint requests to J.M.F. Niermeijer, MD, Department of Neurology and Neurosurgery, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, the Netherlands; e-mail: J.M.F.Niermeijer{at}umcutrecht.nl

We studied the efficacy of fludarabine in 16 patients with immunoglobulin M monoclonal gammopathy of unknown significance polyneuropathy in a prospective uncontrolled trial. The modified Rankin scale improved in 5/16 patients, all of whom had a demyelinating polyneuropathy. The motor conduction velocity improved by more than 10% in two or more nerves for four of five of these patients. Hematologic response in bone marrow occurred in three of five of these patients, whereas two of five already had small polyclonal B cell populations. There were no serious side effects.

Additional material related to this article can be found on the Neurology Web site. Go to www.neurology.org and scroll down the Table of Contents for the December 12 issue to find the title link for this article.

Disclosure: The authors report no conflicts of interest.

Presented in part at the Annual Meeting of the European Neurological Society in Barcelona, Spain, July 2004.

Received November 29, 2005. Accepted in final form August 22, 2006.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2006 by AAN Enterprises, Inc.