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NEUROLOGY 2006;67:2080-2082
© 2006 American Academy of Neurology
Brief Communications

Comprehensive association analysis of the NOS2A gene with Parkinson disease

C. Schulte, M. Sharma, J. C. Mueller, PhD, P. Lichtner, PhD, J. Prestel, MD, D. Berg, MD and T. Gasser, MD

From the Hertie-Institute for Clinical Brain Research (C.S., M.S., J.C.M., J.P., D.B., T.G.), Department for Neurodegenerative Diseases, University of Tübingen, Germany; Institute for Medical Statistics and Epidemiology and Institute for Psychiatry and Psychotherapy (J.C.M.), Technical University Munich, Munich, Germany; and Institute of Human Genetics (P.L.), GSF National Research Center for Environment and Health, Neuherberg, Germany.

Address correspondence and reprint requests to Prof. Dr. med. Thomas Gasser, Hertie-Institute for Clinical Brain Research, Section for Neurodegenerative Diseases, University of Tübingen, Hoppe-Seyler Str. 3, 72076 Tübingen, Germany; e-mail: thomas.gasser{at}med.uni-tuebingen.de

Inducible nitric oxide synthase (NOS2A) may be involved in the oxidative stress pathology of Parkinson disease (PD). Two previous studies reported an association of a single nucleotide polymorphism (rs1060826) with PD. A replication study of 340 German patients and 680 controls showed no significant association between 12 genotyped polymorphisms and PD. NOS2A is therefore not a major susceptibility locus in our relatively young sample population.

Additional material related to this article can be found on the Neurology Web site. Go to www.neurology.org and scroll down the Table of Contents for the December 12 issue to find the title link for this article.

Funded by the German National Genome Network (NGFN2; German Ministry for Education and Research) and the Competence Network PD (German Ministry for Education and Research).

Disclosure: The authors report no conflicts of interest.

Received March 2, 2006. Accepted in final form August 30, 2006.






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