Neurology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow CME: Take the course for this article:
 Volume 67, Number 12, December 26, 2006
Right arrow Data Supplement
Right arrow Italian Translation
Right arrow Correspondence:
Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Leone, M. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Leone, M. A.
Related Collections
Right arrow Prognosis
Right arrow All Epilepsy/Seizures
Right arrow Antiepileptic drugs
Right arrowRelated Article
NEUROLOGY 2006;67:2227-2229
© 2006 American Academy of Neurology
Brief Communications

Treatment of the first tonic-clonic seizure does not affect long-term remission of epilepsy

Maurizio A. Leone, MD, Alessandra Solari, MD, Ettore Beghi, MD for the FIRST Group*

From the Clinica Neurologica (M.A.L.), "Ospedale Maggiore della Carità," Novara, Istituto Nazionale Neurologico "C. Besta" (A.S.), Milano, Centro per l'Epilessia (E.B.), Università di Milano–Bicocca, Monza, and Laboratorio di Malattie Neurologiche (M.A.L., E.B.), Istituto Mario Negri, Milano, Italy.

Address correspondence and reprint requests to Dr Leone, Clinica Neurologica, Ospedale Maggiore della Carità, C.so Mazzini, 18-28100 Novara, Italy; e-mail: maurizio.leone{at}maggioreosp.novara.it

We followed 419 patients with a first, unprovoked, primarily or secondarily generalized tonic-clonic seizure, randomized to immediate antiepileptic treatment or to treatment only in the event of seizure recurrence. The probability of achieving a 2-year remission was 72 vs 57% at 3 months, 84 to 79% at 3 years, and 85 to 86% at 10 years (p = NS). The probability of entering 5-year remission was 47 to 40, 58 to 58, and 64 to 64% (p = NS). Early treatment does not affect the long-term prognosis of epilepsy.

Additional material related to this article can be found on the Neurology Web site. Go to www.neurology.org and scroll down the Table of Contents for the December 26 issue to find the title link for this article.

* See appendix E-1 at www.neurology.org for a list of investigators participating in the FIRST Group.

Disclosure: The authors report no conflicts of interest.

Received March 29, 2006. Accepted in final form September 20, 2006.


Related Article

December 26 Highlights
Neurology 2006 67: 2102-2103. [Full Text] [PDF]



This article has been cited by other articles:


Home page
 NeurologyHome page
B. G. Vickrey
When the patient knows best: A challenge in translating clinical trial evidence into practice
Neurology, April 10, 2007; 68(15): 1172 - 1173.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2006 by AAN Enterprises, Inc.