Neurology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Correspondence:
Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Valdmanis, P. N.
Right arrow Articles by Dupré, N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Valdmanis, P. N.
Right arrow Articles by Dupré, N.
Related Collections
Right arrow Gait disorders/ataxia
Right arrow All Genetics
Right arrow Genetic linkage
NEUROLOGY 2006;67:2239-2242
© 2006 American Academy of Neurology
Brief Communications

A founder haplotype for autosomal dominant sensory ataxia in Eastern Canada

P. N. Valdmanis, BSc, D. Brunet, MD, J. St-Onge, L. Weston, MD, G. A. Rouleau, MD, PhD and N. Dupré, MD, MSc

From the Center for the Study of Brain Diseases (P.N.V., G.A.R., J.S.-O., N.D.), CHUM Research Center, Notre-Dame Hospital, Montreal, QC, Canada; Department of Neurological Sciences (D.B., N.D.), CHAUQ, Enfant-Jésus, Quebec City, QC, Canada; Moncton Hospital (L.W.), Moncton, NB, Canada.

Address correspondence and reprint requests to Dr. Nicolas Dupré, Department of Neurological Sciences, CHAUQ, Enfant-Jésus, 1401, 18th Street, Quebec City, QC, Canada G1J 1Z4; e-mail: nicolas.dupre{at}cha.quebec.qc.ca

We present phenotypic and genotypic data for an additional family with autosomal dominant sensory ataxia, a disease characterized by gait difficulties associated with diminished sensation in the limbs and areflexia. The same disease haplotype spanning the entire SNAX1 locus is observed in affected members of this second family, enabling the locus to be reduced to a 7.3-cM interval.

The Canadian Institute of Health Research funded this study and supported N.D. and P.N.V.

Disclosure: The authors report no conflicts of interest.

Received December 21, 2005. Accepted in final form September 5, 2006.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2006 by AAN Enterprises, Inc.