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NEUROLOGY 2006;67:2253-2255
© 2006 American Academy of Neurology
Brief Communications

Efficacy of oxcarbazepine for prophylaxis against cumulative oxaliplatin-induced neuropathy

A. A. Argyriou, MD, E. Chroni, MD, PhD, P. Polychronopoulos, MD, G. Iconomou, PhD, A. Koutras, MD, PhD, T. Makatsoris, MD, M. K. Gerolymos, MD, P. Gourzis, MD, K. Assimakopoulos, MD and H. P. Kalofonos, MD, PhD

From the Department of Neurology, EMG/ENG Laboratory (A.A.A., E.C., P.P.) and Department of Medicine, Division of Oncology (G.I., A.K., T.M., M.K.G., P.G., K.A., H.P.K.), University of Patras Medical School, Rion-Patras, Greece.

Address correspondence and reprint requests to Dr. Andreas A. Argyriou, Neurology Department, EMG/ENG Laboratory, University of Patras Medical School, 26504, Rion-Patras, Greece; e-mail: andargyriou{at}yahoo.gr

We conducted a randomized, open-label, controlled trial to assess the efficacy of oxcarbazepine for prophylaxis against oxaliplatin-induced peripheral neuropathy (OxIN). Thirty-two patients with colon cancer received 12 courses of the FOLFOX-4 regimen and were randomly assigned to receive oxcarbazepine (600 mg BID) or chemotherapy without oxcarbazepine. The incidence of OxIN was strikingly decreased in patients receiving oxcarbazepine (31.2% vs 75%). Oxcarbazepine may prevent OxIN symptoms. Further larger placebo-controlled trials are warranted to confirm our results.

Disclosure: The authors report no conflicts of interest.

Received June 15, 2006. Accepted in final form September 15, 2006.


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