Neurology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Spanish Translation
Right arrow Correspondence:
Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Argyriou, A. A.
Right arrow Articles by Kalofonos, H. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Argyriou, A. A.
Right arrow Articles by Kalofonos, H. P.
Related Collections
Right arrow Peripheral neuropathy
Right arrow All Clinical trials
Right arrow Chemotherapy-tumor
Right arrow Clinical trials Observational study (Cohort, Case control)
Right arrow Antiepileptic drugs
Right arrowRelated Article
NEUROLOGY 2006;67:2253-2255
© 2006 American Academy of Neurology
Brief Communications

Efficacy of oxcarbazepine for prophylaxis against cumulative oxaliplatin-induced neuropathy

A. A. Argyriou, MD, E. Chroni, MD, PhD, P. Polychronopoulos, MD, G. Iconomou, PhD, A. Koutras, MD, PhD, T. Makatsoris, MD, M. K. Gerolymos, MD, P. Gourzis, MD, K. Assimakopoulos, MD and H. P. Kalofonos, MD, PhD

From the Department of Neurology, EMG/ENG Laboratory (A.A.A., E.C., P.P.) and Department of Medicine, Division of Oncology (G.I., A.K., T.M., M.K.G., P.G., K.A., H.P.K.), University of Patras Medical School, Rion-Patras, Greece.

Address correspondence and reprint requests to Dr. Andreas A. Argyriou, Neurology Department, EMG/ENG Laboratory, University of Patras Medical School, 26504, Rion-Patras, Greece; e-mail: andargyriou{at}yahoo.gr

We conducted a randomized, open-label, controlled trial to assess the efficacy of oxcarbazepine for prophylaxis against oxaliplatin-induced peripheral neuropathy (OxIN). Thirty-two patients with colon cancer received 12 courses of the FOLFOX-4 regimen and were randomly assigned to receive oxcarbazepine (600 mg BID) or chemotherapy without oxcarbazepine. The incidence of OxIN was strikingly decreased in patients receiving oxcarbazepine (31.2% vs 75%). Oxcarbazepine may prevent OxIN symptoms. Further larger placebo-controlled trials are warranted to confirm our results.

Disclosure: The authors report no conflicts of interest.

Received June 15, 2006. Accepted in final form September 15, 2006.


Related Article

December 26 Highlights
Neurology 2006 67: 2102-2103. [Full Text] [PDF]



This article has been cited by other articles:


Home page
 The OncologistHome page
A. A. Argyriou, P. Polychronopoulos, and E. Chroni
The Usefulness of Nerve Conduction Studies in Objectively Assessing Oxaliplatin-Induced Peripheral Neuropathy
Oncologist, November 1, 2007; 12(11): 1371 - 1372.
[Full Text] [PDF]

Home page
 The OncologistHome page
W.-S. Wang, J.-K. Lin, T.-C. Lin, W.-S. Chen, J.-K. Jiang, H.-S. Wang, T.-J. Chiou, J.-H. Liu, C.-C. Yen, and P.-M. Chen
In Reply
Oncologist, November 1, 2007; 12(11): 1372 - 1373.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2006 by AAN Enterprises, Inc.