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RLS3: Fine-mapping of an autosomal dominant locus in a family with intrafamilial heterogeneity

From the Department of Clinical Neurophysiology (K.M.L., C.T.), Georg-August-University, Goettingen; RG Neurological Genetics (J.W.), RG Computational Genetics (B.P., B.M.-M.), Max Planck Institute of Psychiatry, Munich, Germany; Institute of Human Genetics (J.W.), GSF National Research Center, Munich, Germany; Department of Neurology (M.D.), Ludwig Maximilians University of Munich, Klinikum Grosshadern, Munich; and Hertie-Institute for Clinical Brain Research, Department of Neurodegenerative Diseases (T.G.), University of Tübingen, Tübingen, Germany.

Address correspondence and reprint requests to Dr. Bertram Müller-Myhsok, Computational Genetics Group, Max-Planck Institute of Psychiatry, Kraepelinstr. 2-10, D-80804 Munich, Germany; e-mail: bmm{at}mpipsykl.mpg.de

A new locus for restless legs syndrome (RLS3) was identified on chromosome 9p24-22. The authors analyzed transmission disequilibrium tests (TDTs) and affecteds-only linkage analysis in one large family of Bavarian origin, taking into account age at onset. P values were 0.0054 for marker D9S1810 for TDT and 0.0009 for the affecteds-only linkage analysis, providing a confirmation of RLS3. This study narrows the region containing the autosomal dominant RLS3 locus to 11.1 cM (16.6 Mbp).

Additional material related to this article can be found on the Neurology Web site. Go to www.neurology.org and scroll down the Table of Contents for the July 25 issue to find the title link for this article.

*These authors contributed equally to this work.

This work was partially funded by the Deutsche Forschungsgemeinschaft KFO 113/1.

Disclosure: The authors report no conflicts of interest.

Received August 9, 2005. Accepted in final form March 20, 2006.

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