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NEUROLOGY 2006;67:322-323
© 2006 American Academy of Neurology
Brief Communications

Occupational manganese neurotoxicity provoked by hepatitis C

Herbert H. Schaumburg, MD, Steven Herskovitz, MD and Victoria A. Cassano, MD

From the Department of Neurology (H.H.S., S.H.), Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY; and Occupational Medicine Services (V.A.C.), Hartford Medical Group, Wethersfield, CT.

Address correspondence and reprint requests to Dr. Herbert H. Schaumburg, Department of Neurology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461; e-mail: schaumbu{at}aecom.yu.edu

Manganese neurotoxicity developed in a highly exposed worker after asymptomatic, moderate hepatic dysfunction from hepatitis C infection. Antiviral therapy was accompanied by resolution of increased blood manganese levels and neurologic improvement. Even asymptomatic hepatic dysfunction may impair manganese clearance and place highly exposed persons at risk for toxicity.

Disclosure: The authors report no conflicts of interest.

Received November 17, 2005. Accepted in final form March 23, 2006.




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