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NEUROLOGY 2006;67:324-326
© 2006 American Academy of Neurology
Brief Communications

Combined IV–intra-arterial thrombolysis: A color-coded duplex pilot study

F. Perren, MD, J. Loulidi, MD, R. Graves, PhD, H. Yilmaz, MD, D. Rüfenacht, MD, T. Landis, MD and R. Sztajzel, MD

From the Departments of Neurology (F.P., J.L., T.L., R.S.) and Neuroradiology (H.Y., D.R.), University Hospital and Medical School of Geneva, Geneva, Switzerland; and Department of Psychology (R.G.), University of Victoria, Victoria, Canada.

Address correspondence and reprint requests to Dr. Fabienne Perren, University Hospital and Medical School of Geneva, Department of Neurology, Micheli-du-Crest 24, CH-1211 Geneva 14, Switzerland; e-mail: fabienne.perren{at}hcuge.ch

The authors compared the transcranial color-coded duplex pattern of the middle cerebral arteries (MCAs) before and after IV and combined IV–intra-arterial (IV–IA) thrombolysis in consecutive first-ever stroke patients. Patients receiving combined IV–IA thrombolysis showed greater improvement in flow signal and higher incidence of complete MCA recanalization vs those receiving IV thrombolysis, especially when the MCA was occluded or had only minimal flow.

This study was supported by the "fonds de perequation" of the University Hospital of Geneva.

Disclosure: The authors report no conflicts of interest.

Received July 27, 2005. Accepted in final form March 20, 2006.






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