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NEUROLOGY 2006;67:340-342
© 2006 American Academy of Neurology
Brief Communications

Sodium valproate vs phenytoin in status epilepticus: A pilot study

U. K. Misra, DM, Jayantee Kalita, DM and Rajesh Patel, DM

From the Department of Neurology, Sanjay Gandhi PGIMS, Lucknow, India.

Address correspondence and reprint requests to Dr Misra, Department of Neurology, Sanjay Gandhi PGIMS, Lucknow 226014, India; e-mail: drukmisra{at}rediffmail.com

Sixty-eight patients with convulsive status epilepticus (SE) were randomly assigned to two groups to study the efficacy of sodium valproate (VPA) and phenytoin (PHT). Seizures were aborted in 66% in the VPA group and 42% in the PHT group. As a second choice in refractory patients, VPA was effective in 79% and PHT was effective in 25%. The side effects in the two groups did not differ. Sodium valproate may be preferred in convulsive SE because of its higher efficacy.

Disclosure: The authors report no conflicts of interest.

Received July 26, 2005. Accepted in final form March 20, 2006.




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Correspondence:

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Sodium valproate vs phenytoin in status epilepticus: A pilot study
Andrea O. Rossetti
Neurology Online, 19 Sep 2006 [Full text]
Reply from the Authors
Usha Kant Misra, et al.
Neurology Online, 19 Sep 2006 [Full text]