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NEUROLOGY 2006;67:350-352
© 2006 American Academy of Neurology
Brief Communications

Subtle cognitive dysfunction in adult onset myotonic dystrophy type 1 (DM1) and type 2 (DM2)

C. Gaul, MD, T. Schmidt, G. Windisch, T. Wieser, MD, T. Müller, MD, S. Vielhaber, MD, S. Zierz, MD and B. Leplow, PhD

From the Departments of Neurology (C.G., T.W., T.M., S.Z.) and Clinical Psychology and Psychotherapy (T.S., G.W., B.L.), Martin-Luther-University of Halle-Wittenberg, Halle/Saale, Germany; Department of Neurology II (S.V.), Otto-von-Guericke-University of Magdeburg, Magdeburg, Germany.

Address correspondence and reprint requests to Dr. Charly Gaul, Department of Neurology, Martin-Luther-University of Halle-Wittenberg, Ernst-Grube-Strasse 40, D-06097 Halle/Saale, Germany; e-mail: Charly.Gaul{at}gmx.de

The authors performed neuropsychological testing in 21 patients with myotonic dystrophy type 1 (DM1) and 21 with type 2 (DM2) and healthy controls. They detected no general cognitive deficit in either DM1 or DM2, but compared to controls, both groups of patients were inferior in tests of prefrontal functioning. Patient groups did not differ in any measure. Mood status was not related to neuropsychological performance. This is consistent with findings of executive dysfunction in both DM1 and DM2.

C.G. was supported by the Roux-Grant of the Martin-Luther-University of Halle-Wittenberg.

Parts of this paper were presented at the 15th Meeting of the European Neurologic Society, Vienna, 2005.

Disclosure: The authors report no conflicts of interest.

Received September 19, 2005. Accepted in final form March 17, 2006.






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