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NEUROLOGY 2006;67:356-358
© 2006 American Academy of Neurology
Brief Communications

Identification of subgroups in amnestic mild cognitive impairment

E. Guedj, MD, E. J. Barbeau, PhD, M. Didic, MD, O. Felician, MD, PhD, C. de Laforte, MD, M. Ceccaldi, MD, PhD, O. Mundler, MD, PhD and M. Poncet, MD

From Service Central de Biophysique et de Médecine Nucléaire, AP-HM Timone, Marseille, France (E.G., C.d.L., O.M.); Centre de Recherche Cerveau et Cognition, CNRS UMR-5549 and Université Paul Sabatier Toulouse 3, Toulouse, France (E.J.B.); and Service de Neurologie et de Neuropsychologie AP-HM Timone and Laboratoire de Neurophysiologie et de Neuropsychologie, INSERM U751, Marseille, France (M.D., O.F., M.C., M.P.).

Address correspondence and reprint requests to Dr. Eric Guedj, Service Central de Biophysique et de Médecine Nucléaire, Assistance Publique des Hôpitaux de Marseille, Centre Hospitalo-Universitaire de la Timone, 264, rue Saint Pierre, 13385 Marseille Cedex 5, France; e-mail: eric.guedj{at}ap-hm.fr

The DMS48 is a visual recognition memory test designed to detect memory changes in early Alzheimer disease (AD). Patients with amnestic mild cognitive impairment (aMCI) who succeeded on this task exhibited frontal hypoperfusion on SPECT. In contrast, failure was associated with temporomesial and temporoparietal hypoperfusion, a pattern usually described in the early stages of AD. It may possible to detect patients at high risk for AD within a population of aMCI.

Supported by AP-HM PHRC 2001/54.

Disclosure: The authors report no conflicts of interest.

The DMS48, a test designed for research purposes, can be downloaded at the following address: http://www.sf-neuro.org (Greco file; compulsory free registration).

Received December 21, 2005. Accepted in final form March 22, 2006.




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