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From the Departments of Neurology (S.E., A.R., C.K., I.W.H., A.F.) and Neuropaediatrics (G.K., O.D.), University of Münster, Germany.
Address correspondence and reprint requests to Dr. S. Evers, Department of Neurology, University of Münster, Albert-Schweitzer-Str. 33, Germany; e-mail: everss{at}uni-muenster.de
The authors conducted a double-blind, placebo-controlled, crossover study to investigate the efficacy of oral zolmitriptan in the treatment of migraine in children and adolescents. Patients (n = 32) received placebo, zolmitriptan 2.5 mg, and ibuprofen 200 to 400 mg to treat three consecutive migraine attacks. Pain relief rates after 2 hours were 28% for placebo, 62% for zolmitriptan, and 69% for ibuprofen (p < 0.05). Both drugs are well tolerated with only mild side effects.
This article was previously published in electronic format as an Expedited E-pub on June 14, 2006, at www.neurology.org.
Disclosure: The authors report no conflicts of interest.
Received October 3, 2005.
Accepted in final form March 27, 2006.
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