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NEUROLOGY 2006;67:505-507
© 2006 American Academy of Neurology
Brief Communications

Anti-MuSK antibodies: Correlation with myasthenia gravis severity

E. Bartoccioni, PhD, F. Scuderi, PhD, G. M. Minicuci, MD, M. Marino, PhD, F. Ciaraffa, MD and A. Evoli, MD

From the Departments of General Pathology (E.B., F.S., M.M.) and Neurosciences (A.E., F.C., G.M.M.), Catholic University, Rome, Italy.

Address correspondence and reprint requests to Dr. A. Evoli, Neuroscience Department, Catholic University, L.go F. Vito,1-00168 Roma, Italy; e-mail: a.evoli{at}rm.unicatt.it

The authors measured anti–muscle-specific tyrosine kinase (anti-MuSK) antibodies (Abs) in 83 serum samples from 40 patients and evaluated their correlation with myasthenia gravis severity and treatment response. Ab concentrations were often reduced by immunosuppression but not after thymectomy. Both in individual cases and in the whole population, a correlation between Ab levels and disease severity was found.

Additional material related to this article can be found on the Neurology Web site. Go to www.neurology.org and scroll down the Table of Contents for the August 8 issue to find the title link for this article.

Supported by Catholic University grants to E.B. and A.E.

Disclosure: The authors report no conflicts of interest.

Received December 12, 2005. Accepted in final form March 27, 2006.




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