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NEUROLOGY 2006;67:528-530
© 2006 American Academy of Neurology
Brief Communications

Treatment monitoring and response prediction with proton MR spectroscopy in AD

F. Jessen, MD, F. Traeber, PhD, K. Freymann, Dipl-Psych, W. Maier, MD, H. H. Schild, MD and W. Block, PhD

From the Departments of Psychiatry (F.J., K.F., W.M.) and Radiology (F.T., H.H.S., W.B.), University of Bonn, Germany.

Address correspondence and reprint requests to Dr. Frank Jessen, Department of Psychiatry, University of Bonn, Sigmund-Freud-Str. 25, 53105 Bonn, Germany; e-mail: jessen{at}uni-bonn.de

In this proton magnetic resonance spectroscopy (1H-MRS) study, the authors correlated cognitive improvement after 3 months of treatment with donepezil with changes of N-acetylaspartate (NAA) level and NAA/Creatine (Cr) ratio in the medial temporal and parietal lobe of 17 patients with Alzheimer disease. Treatment response was associated with an increase of NAA and NAA/Cr in the parietal lobe. Low baseline NAA/Cr in the parietal lobe predicted positive treatment outcome.

Additional material related to this article can be found on the Neurology Web site. Go to www.neurology.org and scroll down the Table of Contents for the August 8 issue to find the title link for this article.

Sponsored by Pfizer Inc. and the German Research Network on Dementia, German Federal Ministry for Education and Research (grant 01GI0102).

Disclosure: The authors report no conflicts of interest.

Received May 19, 2005. Accepted in final form March 28, 2006.




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