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NEUROLOGY 2006;67:531-533
© 2006 American Academy of Neurology
Brief Communications

The MM2-cortical form of sporadic Creutzfeldt–Jakob disease presenting with visual disturbance

I. Nozaki, MD, T. Hamaguchi, MD, PhD, M. Noguchi-Shinohara, MD, K. Ono, MD, PhD, H. Shirasaki, MD, K. Komai, MD, PhD, T. Kitamoto, MD, PhD and M. Yamada, MD, PhD

From the Department of Neurology and Neurobiology of Aging (I.N., T.H., M.N.-S., K.O., K.K., M.Y.), Kanazawa University Graduate School of Medical Science, Kanazawa; Department of Neurology (H.S.), Tonami General Hospital, Tonami; and Department of Prion Protein Research, Division of CJD Science and Technology (T.K.), Tohoku University Graduate School of Medicine, Sendai, Japan.

Address correspondence and reprint requests to Dr. Ichiro Nozaki, Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science, 13-1 Takara-machi, Kanazawa, Ishikawa 920-8640, Japan; e-mail: ichi51{at}med.kanazawa-u.ac.jp

A subclass of sporadic Creutzfeldt–Jakob disease (sCJD) characterized by onset with visual symptoms (Heidenhain variant) has been reported to belong to the MM1 or MV1 type according to Parchi's classification. The authors report a 65-year-old woman with MM2-cortical sCJD with slowly progressive visual disturbance as the initial symptom. Diffusion-weighted MRIs revealed hyperintensity in both occipital cortices at an early stage.

Disclosure: The authors report no conflicts of interest.

Received December 1, 2005. Accepted in final form March 28, 2006.






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