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This Article Full Text Full Text (PDF) CME: Take the course for this article: Volume 67, Number 4, August 22, 2006 Correspondence: Submit a response Correspondence: View responses Alert me when this article is cited Alert me when Correspondence are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Friedman, J. H. Search for Related Content PubMed PubMed Citation Articles by Friedman, J. H. Related Collections Parkinson's disease/Parkinsonism All Psychiatric disorders

Atypical antipsychotics in the elderly with Parkinson disease and the "black box" warning

From the NeuroHealth Parkinson’s Disease and Movement Disorders Center, Warwick, RI.

Address correspondence and reprint requests to Dr Friedman, NeuroHealth Parkinson’s Disease and Movement Disorders Center, 227 Centerville Rd., Warwick, RI 02886; e-mail: Joseph_Friedman{at}Brown.edu

In the last 2 years, regulatory agencies in the UK and the USA have made recommendations and "black box" warnings, regarding the use of atypical antipsychotic drugs in the elderly because of a purported increase in risk of stroke and death in elderly demented patients. These advisories did not address the adverse effects of "typical" (first-generation) antipsychotics. In this article, the author reviews the history of these developments and raises issues that still need to be addressed by the neurologic community.

Disclosure: Dr. Friedman has received remuneration within the last 12 months for speaking fees, consultation or performing clinical research from the following involved companies: Astra-Zeneca, Janssen, Acadia, Ovation, Novartis.

Received December 27, 2005. Accepted in final form May 8, 2006.

This article has been cited by other articles:

				C. E. Rosenkilde and J. H. Friedman Atypical antipsychotics in the elderly with Parkinson disease and the "black box" warning Neurology, April 17, 2007; 68(16): 1325 - 1326. [Full Text] [PDF]

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