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Endothelial dysfunction in cold type complex regional pain syndrome

From the Division of Neurological Pain Research and Therapy, Department of Neurology, University Hospital of Schleswig-Holstein, Campus Kiel, Kiel, Germany.

Address correspondence and reprint requests to Dr. Joern Schattschneider, Universitätsklinikum Schleswig-Holstein, Campus Kiel, Klinik für Neurologie, Schittenhelmstr. 10, 24103 Kiel, Germany; e-mail: j.schattschneider{at}neurologie.uni-kiel.de

The authors examined endothelial function in cold type chronic complex regional pain syndrome (CRPS) I using acetylcholine- and sodium nitroprusside–induced vasodilation combined with laser Doppler flowmetry in 14 patients and 10 controls. On the affected side, acetylcholine-induced vasodilation was significantly reduced in comparison to controls and the unaffected extremity. No significant differences were found after application of sodium nitroprusside. The results demonstrate impaired endothelial function in chronic CRPS I.

Supported by the Deutsche Forschungsgemeinschaft (DFG Ba 1921/1-3) and the Network "Neuropathic Pain" the German Ministry of Research and Education, German Research Network on Neuropathic Pain (BMBF, 01EM01/04), and an unrestricted educational grant from Pfizer, Germany.

Disclosure: The authors report no conflicts of interest

Received October 10, 2005. Accepted in final form April 14, 2006.

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