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Structural changes in patients with primary generalized tonic and clonic seizures

From the Department of Clinical Neuroscience, Division of Neurology, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden.

Address correspondence and reprint requests to Dr. I. Savic, Department of Neurology, Karolinska Institutet, Karolinska University Hospital, Department of Clinical Neuroscience, MR Centre, 171 76 Stockholm, Sweden; e-mail: ivanka.savic-berglund{at}neuro.ki.se

We conducted MR volumetry and voxel-based morphometry in 19 patients who had idiopathic generalized epilepsy (IGE) with tonic clonic seizures as the only seizure type and 52 control subjects. Patients exhibited elevated frontal lobe fraction of CSF and reduced fraction of gray matter in the frontal, parietal, temporal cortex, thalamus, and cerebellum. The thalamus and cerebellum also showed reduced volumes, as did the caudate and putamen. Contrary to current diagnostic criteria, regional tissue abnormalities may be present in IGE.

Additional material related to this article can be found on the Neurology Web site. Go to www.neurology.org and scroll down the Table of Contents for the August 22 issue to find the title link for this article.

Supported by the Swedish Medical Research Council (grant 98-14X-12599-01A), Karolinska Institute, and the Magnus Bergvall Foundation.

Disclosure: The authors report no conflicts of interest.

Received November 2, 2005. Accepted in final form April 24, 2006.

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