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Identification and haplotype analysis of LRRK2 G2019S in Japanese patients with Parkinson disease

From the Department of Neurology (C.P.Z., D.Y., A.S.), University of Washington School of Medicine, Seattle; Geriatric Research Education and Clinical Center (C.P.Z., D.Y.) and Northwest Parkinson’s Disease Research Education and Clinical Center (A.S.), VA Puget Sound Health Care System, Seattle; Department of Epidemiology (H.M., H.K.), Research Institute for Radiation Biology and Medicine and Department of Clinical Neuroscience and Therapeutics (H.M.), Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan; Department of Neuropsychiatry (H.U.), Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan; Department of Neurology (M.Y.), Kagawa Prefectural Central Hospital, Takamatsu, Japan; Department of Neurology (M.O.), Sumitomo Hospital, Osaka, Japan; Department of Clinical Neuroscience (Y.I., R.K.), Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan; Booth Gardner Parkinson’s Care Center (A.G., B.C.L.), Evergreen Hospital Medical Center, Kirkland, WA; Virginia Mason Medical Center (J.W.R.), Seattle.

Address correspondence and reprint requests to Dr. Cyrus P. Zabetian, Geriatric Research Education and Clinical Center, S-182, VA Puget Sound Health Care System, 1660 South Columbian Way, Seattle, WA 98108; e-mail: zabetian{at}u.washington.edu

LRRK2 G2019S is the most common known cause of Parkinson disease (PD) in patients of European origin, but little is known about its distribution in other populations. The authors identified two of 586 Japanese patients with PD heterozygous for the mutation who shared a haplotype distinct from that observed in Europeans. This suggests that G2019S originated from separate founders in Europe and Japan and is more widely dispersed than previously recognized.

This article was previously published in eletronic format as an Expedited E-Pub on May 25, 2006, at www.neurology.org.

Supported by the Geriatric and Mental Illness Research Education and Clinical Centers, VA Puget Sound Health Care System, and grants from the NIH (K08-NS044138), Department of Veterans Affairs (Merit Review Award), PD Foundation, and American PD Association (C.P.Z.).

Disclosure: The authors report no conflicts of interest.

Received February 7, 2006. Accepted in final form April 11, 2006.

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