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Occurrence of sleep disorders in the families of narcoleptic patients

From Stanford Sleep Epidemiology (M.M.O.) and Center for Narcolepsy (M.L.O.), School of Medicine, Stanford University, CA.

Address correspondence and reprint requests to Dr. Maurice M. Ohayon, Stanford Sleep Epidemiology, School of Medicine, Stanford University, 3430 W. Bayshore Road, Palo Alto, CA 94303; e-mail: mohayon{at}stanford.edu

First-degree relatives of narcoleptic subjects (probands) may have sleep pathology related to the transmission of the disorder through their family members. The authors examined four groups: probands (n = 96), first-degree relative (n = 337), environmental reference (n = 85), and general population (n = 6,694) groups. Compared with the general population, family members have a 75-fold increased risk for narcolepsy. They are also at greater risk for insufficient sleep syndrome (odds ratio [OR] 6.1), nocturnal eating (OR 5.7), and adjustment sleep disorder (OR 3.1).

M.M.O. is supported by an NIH grant (no. 5R01NS044199).

Disclosure: The authors report no conflicts of interest.

Received September 22, 2005., Accepted in final form April 19, 2006.