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Estrogen therapy and cognition: A 6-year single-blind follow-up study in postmenopausal women

From the Department of Psychology (P.A.) and Sleep Research Unit, Department of Physiology (P.A., P.P.-K.), University of Turku, Turku, Finland; and Department of Obstetrics and Gynecology (P.P.-K., R.E.) and Department of Neurology (R.P.), Turku University Central Hospital, Turku, Finland.

Address correspondence and reprint requests to Paula Alhola: Department of Psychology, University of Turku, FI-20014 Turku, Finland; e-mail: paula.alhola{at}utu.fi

The authors evaluated the effect of long-term hormone therapy (HT) on cognition in 60 postmenopausal women (aged 53 to 72 years) in a single-blind, 6-year follow-up study. The subjects were divided into three groups: non–HT users, continuous HT users, and irregular HT users. Measures of verbal and visuomotor skills, verbal and visual memory, and attention were used. All women had well-maintained cognitive performance. Long-term HT did not affect cognition, either for better or for worse.

This study was supported by Turku University Foundation and Finnish Cultural Foundation.

Disclosure: The authors report no conflicts of interest.

Received October 12, 2005. Accepted in final form April 20, 2006.

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