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Occurrence of CNS demyelinating disease in patients with myasthenia gravis

From the Departments of Neurology (M.G., O.A.) and Pathology (Y.F.), Agnes Ginges Center for Human Neurogenetics, Hadassah University Hospital, Jerusalem, Israel.

Address correspondence and reprint requests to Dr. Marc Gotkine, Department of Neurology, Hadassah University Hospital, POB 12000, Jerusalem 91120, Israel; e-mail: marclana{at}012.net.il

An increased incidence of multiple sclerosis (MS) has been reported in patients with myasthenia gravis (MG). We reviewed records of 214 patients with MG. CNS demyelinating disease (CNSDD) occurred in five patients (2.3%). CNSDD always occurred after the diagnosis of MG. Myelitis (including recurrent myelitis) was the most common CNS manifestation. All patients had antinuclear antibodies. CNSDD occurs more frequently in patients with MG and may be related to immune-modulating treatments including thymectomy.

Additional material related to this article can be found on the Neurology Web site. Go to www.neurology.org and scroll down the Table of Contents for the September 12 issue to find the title link for this article.

Disclosure: The authors report no conflicts of interest.

Received December 16, 2005. Accepted in final form April 26, 2006.

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				R. Eichel, Z. Meiner, O. Abramsky, and M. Gotkine Acute Disseminating Encephalomyelitis in Neuromyelitis Optica: Closing the Floodgates Arch Neurol, February 1, 2008; 65(2): 267 - 271. [Abstract] [Full Text] [PDF]

				B. G. Weinshenker, A. Jacob, I. Kister, J. Herbert, M. L. Swerdlow, R. Bergamaschi, G. Piccolo, J. Oger, K. Ikeda, Y. Araki, et al. Occurrence of CNS demyelinating disease in patients with myasthenia gravis. Neurology, April 17, 2007; 68(16): 1326 - 1326. [Full Text] [PDF]

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