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NEUROLOGY 2006;67:900-901
© 2006 American Academy of Neurology
Brief Communications

A novel autosomal dominant restless legs syndrome locus maps to chromosome 20p13

A. Levchenko, MSc, S. Provost, MSc, J. Y. Montplaisir, MD, PhD, L. Xiong, MD, PhD, J. St-Onge, DEC, P. Thibodeau, BSc, J. B. Rivière, BSc, A. Desautels, PhD, G. Turecki, MD, PhD, M. P. Dubé, PhD and G. A. Rouleau, MD, PhD

From the Center for the Study of Brain Diseases, CHUM Research Center–Notre Dame Hospital, Montreal, Quebec, Canada (A.L., L.X., J.S., P.T., J.-B.R., G.A.R.); Montreal Heart Institute Research Center, Montreal, Quebec, Canada (S.P., M.-P.D.); Sleep Disorders Center, Sacré-Coeur Hospital of Montreal, Quebec, Canada (J.-Y.M.); Research Center, Douglas Hospital, Verdun, Quebec, Canada (A.D., G.T.); and Department of Medicine, University of Montreal, Montreal, Quebec, Canada (M.-P.D., G.A.R.).

Address correspondence and reprint requests to Dr. Guy A. Rouleau, Center for the Study of Brain Diseases, CHUM Research Center–Notre Dame Hospital, J.A. de Sève Pavilion, Room Y-3633-1, 1560, Sherbrooke Street East, Montreal, Quebec H2L 4M1, Canada; e-mail: guy.rouleau{at}umontreal.ca.

The authors investigated genetic factors contributing to restless legs syndrome (RLS) by performing a 10-cM genome-wide scan in a large French-Canadian pedigree. They detected an autosomal-dominant locus mapping to chromosome 20p13, with a maximum multipoint lod score of 3.86 at marker D20S849. This is the third reported autosomal-dominant locus for RLS and the first autosomal-dominant RLS locus in the French-Canadian population.

Additional material related to this article can be found on the Neurology Web site. Go to www.neurology.org and scroll down the Table of Contents for the September 12 issue to find the title link for this article.

This work was supported by the Canadian Institutes of Health Research with a grant (G.A.R., #MOP-64224) and the Canada Graduate Scholarships Doctoral Award (A.L.).

Disclosure: The authors report no conflicts of interest.

Received December 16, 2005. Accepted in final form May 9, 2006.




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