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NEUROLOGY 2006;67:905-907
© 2006 American Academy of Neurology
Brief Communications

Treatment of the gravity dependence of downbeat nystagmus with 3,4-diaminopyridine

A. Sprenger, H. Rambold, MD, T. Sander, S. Marti, MD, K. Weber, MD, D. Straumann, MD and C. Helmchen, MD

From the Department of Neurology (H.R., T.S., C.H.), University of Lübeck, Germany; and Department of Neurology (S.M., K.W., D.S.), University of Zürich, Switzerland.

Address correspondence and reprint requests to Dr. C. Helmchen, Department of Neurology, University Lübeck, Ratzeburger Allee 160, D-23538 Lübeck, Germany; e-mail: Christoph.Helmchen{at}neuro.uni-luebeck.de.

The authors examined the effect of 3,4-diaminopyridine (DAP) on the gravity-dependent (GD) vertical ocular drift component of downbeat nystagmus in 11 patients with idiopathic cerebellar ataxia. With the head tilted downward (45°), DAP reduced slow phase velocity (SPV) in 7 of 11 patients by 36%. Its efficacy correlated with the GD modulation. DAP minimizes the gravity-independent velocity bias and may improve deficient inhibitory cerebellar control on overacting otolith–ocular reflexes.

Additional material related to this article can be found on the Neurology Web site. Go to www.neurology.org and scroll down the Table of Contents for the September 12 issue to find the title link for this article.

Disclosure: The authors report no conflicts of interest.

Received March 8, 2006. Accepted in final form May 4, 2006.




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