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NEUROLOGY 2006;67:911-913
© 2006 American Academy of Neurology
Brief Communications

Quantification of neurometabolites in subacute sclerosing panencephalitis by 1H-MRS

K. Aydin, MD, B. Tatli, MD, M. Ozkan, PhD, K. Ciftci, PhD, Z. Unal, MD, S. Sani, MD, M. Ozmen, MD, M. Caliskan, MD, N. Aydinli, MD and S. Guven, MD

From the Department of Neuroradiology (K.A.), Department of Pediatric Neurology (B.T., M. Ozmen, M.C., N.A.), and Department of Radiology (S.S.), Istanbul Medical School, Istanbul University, Istanbul; Institute of Biomedical Engineering, Bogazici University, Istanbul (M. Ozkan, K.C.); Department of Radiology, VKV American Hospital, Istanbul (Z.U.); and Department of Pediatrics, Bakirkoy Maternal and Childhood Disease Education Hospital, Bakirkoy, Istanbul, Turkey (S.G.).

Address correspondence and reprint requests to Dr. Kubilay Aydin, Adnan Saygun caddesi, Salih Rustu bey sokak, Ulus Konaklari, No:8/12, Ulus, Istanbul/Turkey; e-mail: dr.aydink{at}superonline.com.

The authors studied 20 patients with subacute sclerosing panencephalitis (SSPE) to investigate the correlations between MRI, magnetic resonance spectroscopy (MRS), and clinical status. MRI findings did not correlate with clinical status. By contrast, all patients had reductions in N-acetyl aspartate (NAA) and increase in myoinositol (mI) (p < 0.01), and NAA and mI concentrations correlated with clinical severity (p < 0.05). During follow-up, NAA continued to decline. 1H-MRS may be a useful measure of disease severity and progression in SSPE.

Additional material related to this article can be found on the Neurology Web site. Go to www.neurology.org and scroll down the Table of Contents for the September 12 issue to find the title link for this article.

Disclosure: The authors report no conflicts of interest.

Received January 23, 2006. Accepted in final form May 3, 2006.




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Correspondence:

Read all Correspondence

Quantification of neurometabolites in subacute sclerosing panencephalitis by 1H-MRS
Banu Anlar
Neurology Online, 7 Nov 2006 [Full text]
Reply from the Authors
Kubilay Aydin
Neurology Online, 7 Nov 2006 [Full text]